Cyclobenzaprine StatPearls NCBI Bookshelf

Share This Post

Cyclobenzaprine StatPearls NCBI Bookshelf

Low back pain is a very common issue — it remains among the top five reasons people see a primary healthcare provider. Most cases of low back pain resolve without medical intervention. If other treatments don’t work to alleviate the pain, providers may recommend a muscle relaxant.

  • Make sure you feel comfortable with your doctor’s approach and treatment plan.
  • Properly discard this product when it is expired or no longer needed.
  • Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
  • Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).

The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen what medications should not be taken with flexeril in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Cyclobenzaprine caused slight to moderate increase in heart rate in animals.

How should this medicine be used?

Before taking cyclobenzaprine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch. The dosage is based on your medical condition and response to treatment.

Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants.

Fibromyalgia: Causes, Symptoms, Diagnosis, and Treatment – Healthnews.com

Fibromyalgia: Causes, Symptoms, Diagnosis, and Treatment.

Posted: Tue, 14 Mar 2023 07:00:00 GMT [source]

One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome). Secondary endpoints included a physician’s evaluation of the presence and extent of palpable muscle spasm.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. If you notice other effects not listed above, contact your doctor or pharmacist. Cyclobenzaprine medications are not DEA Scheduled drugs and, therefore, the potential for misuse and dependence with Flexeril is considered to be relatively low.

Flexeril side effects

These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine. FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended.

A Flexeril overdose can cause severe health problems such as cardiac arrest, dangerously low blood pressure, and seizures. Central nervous system depression, seizures, heart attack, and even death can occur. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.

The extended-release capsule is usually taken with or without food once a day. Do not take this drug for more than 3 weeks without talking to your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs. In two case reports, the authors described patients who quickly developed serotonin syndrome after initiating cyclobenzaprine in the short term.

The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. Prescription muscle relaxers can be effective in treating spasticity, muscle spasms and muscle-related pain. But it’s important to weigh the possible risks of these medications, including their side effects and addiction potential.

Subscribe To Our Newsletter

Get updates and learn from the best

More To Explore

Get in touch for any kind of help and information

drop us a line and keep in touch